The aim of this study was to evaluate the macrocirculatory and microcirculatory effects of treatment with lercanidipine, a new antihypertensive agent acting both on blood pressure and microcirculation in patients with moderate essential hypertension and without vascular disease and in patient with hypertension and vascular disease. In hypertensive subjects target-organ damage associated with high blood pressure may now be objectively documented by noninvasive tests. These alterations constitute a model to evaluate not only the pressure effects of antihypertensive treatment but also the normalization of the peripheral microcirculatory network. With color duplex scanning, flow velocity in the central retinal artery and retinal flow velocity can be measured and with use of laser-Doppler-flowmetry, it is also possible to evaluate microcirculation alterations in hypertensive subjects. These evaluation methods are completely noninvasive and may be used to assess the microcirculatory effects of antihypertensive drugs.

译文

:本研究的目的是评估在患有中度原发性高血压和无血管疾病的患者以及患有高血压和血管疾病的患者中,使用新的降压药lercanidipine治疗大环和微循环的作用。在高血压受试者中,与高血压相关的靶器官损害现在可以通过非侵入性测试客观记录。这些改变构成了一个模型,不仅可以评估降压治疗的压力效果,还可以评估周围微循环网络的正常化。通过彩色双工扫描,可以测量视网膜中央动脉的流速和视网膜流速,并且通过使用激光多普勒血流仪,还可以评估高血压患者的微循环改变。这些评估方法完全是非侵入性的,可用于评估降压药的微循环作用。

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