OBJECTIVES:Lipoprotein oxidation, dyslipidemia, and hypertension are important underlying causes of accelerated atherosclerosis in patients with diabetes mellitus. The potential of antihypertensive medications to reduce lipid oxidation is, therefore, an important determinant in the choice of agents for patients with diabetes mellitus. The aim of this study was to compare the lowering effect of a new dihydropyridine calcium antagonist, lercanidipine, with that of the first angiotensin-receptor blocker, losartan, on low-density lipoprotein (LDL) oxidation. METHODS:Forty patients in metabolically stable condition who had type 2 diabetes mellitus with hypertension were studied in this single-blind, randomized, prospective crossover study, comprising 2 treatment periods of 16 weeks each, separated by a 4-week washout period. LDL oxidation was evaluated by dialdehyde analysis by means of the thiobarbituric acid-reactive substances assay with and without cupric sulfate, as well as determination of conjugated dienes in the LDL lipid extract. RESULTS:Lercanidipine and losartan both significantly reduced the propensity of the serum to oxidize LDL (P =.001). With one method of estimation (conjugated dienes), the effect of lercanidipine was superior to that of losartan (P =.04). Losartan lowered urinary albumin excretion but lercanidipine did not. CONCLUSIONS:Both lercanidipine and losartan attenuate LDL oxidation in patients with type 2 diabetes mellitus and hypertension. This observation may offer insight into the mechanisms of the therapeutic effects of these agents in patients with diabetes mellitus.

译文

目的:脂蛋白氧化,血脂异常和高血压是糖尿病患者加速动脉粥样硬化的重要根本原因。因此,降压药减少脂质氧化的潜力是选择糖尿病患者用药的重要决定因素。这项研究的目的是比较一种新型的二氢吡啶类钙拮抗剂lercanidipine和第一种血管紧张素受体阻滞剂losartan对低密度脂蛋白(LDL)氧化的降低作用。
方法:在这项单盲,随机,前瞻性交叉研究中,对40名代谢稳定状态的2型糖尿病合并高血压患者进行了研究,该研究包括2个治疗期,每个治疗期16周,相隔4周的清除期。 LDL的氧化通过二醛分析来评估,方法是在有或没有硫酸铜的情况下,通过硫代巴比妥酸反应性物质测定,以及测定LDL脂质提取物中的共轭二烯。
结果:乐卡地平和氯沙坦均显着降低了血清氧化低密度脂蛋白的倾向(P = .001)。用一种估计方法(共轭二烯),乐卡地平的作用优于氯沙坦(P = .04)。氯沙坦可降低尿白蛋白排泄量,而乐卡地平则不能。
结论:lercanidipine和losartan均可减轻2型糖尿病和高血压患者的LDL氧化。该观察结果可以提供对这些药物对糖尿病患者的治疗作用机理的见解。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录