The objective of this study was to confirm whether hemoglobin (Hb) levels during chemoradiotherapy are associated with survival in patients with locally advanced cervical carcinoma and to assess impact of the Hb level on survival according to lymph node (LN) metastasis. A retrospective review of 85 cervical carcinoma patients treated with concurrent chemoradiotherapy was conducted. The stage of disease ranged between FIGO stage IB and stage IVA. Disease-free and overall survivals were evaluated by univariate and multivariate analyses. After median follow-up of 35.7 months, 24 patients developed recurrence of disease and 14 patients died from their disease. Stage, LN metastasis, and squamous cell carcinoma antigen and Hb levels during chemoradiation were correlated significantly with survival (P < 0.05). Maintenance of Hb above 10.0 g/dL was associated with better survival (P < 0.05). However, no such benefits were observed in patients with LN metastasis by magnetic resonance imaging (MRI). Multivariate Cox regression hazard model showed that Hb levels during chemoradiation were an independent prognostic factor in patients without LN metastasis by MRI. Maintenance of Hb during chemoradiation is of benefit in cervical carcinoma patients without LN metastasis but not with LN metastasis by MRI.

译文

:本研究的目的是确定化学放疗期间血红蛋白(Hb)水平是否与局部晚期宫颈癌患者的生存相关,并根据淋巴结(LN)转移评估Hb水平对生存的影响。回顾性回顾了85例同时放化疗的宫颈癌患者。疾病的阶段在FIGO的IB阶段和IVA阶段之间。通过单因素和多因素分析评估无病生存期和总生存期。在中位随访35.7个月后,有24例患者复发疾病,有14例患者死于疾病。化学放疗期间的分期,LN转移,鳞状细胞癌抗原和血红蛋白水平与生存率显着相关(P <0.05)。维持Hb高于10.0 g / dL与更好的生存率相关(P <0.05)。但是,通过磁共振成像(MRI)在LN转移患者中未观察到此类益处。多元Cox回归风险模型显示,放化疗期间Hb水平是无LN转移的患者(通过MRI)的独立预后因素。对于没有LN转移但没有MRI的LN转移的宫颈癌患者,放化疗期间维持Hb有益。

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