Interleukin-1 (IL-1) has been implicated in chronic and acute cerebral neuropathologies. IL-1 receptor antagonist (IL-1ra), a naturally occurring protein that binds to IL-1 receptors without inducing signal transduction, blocks several actions of IL-1. IL-1ra acts at the local level and it also circulates in the bloodstream. We now report evidence for a biological function of IL-1ra in the brain as an endogenous neuroprotective molecule. Cerebral expression of IL-1ra mRNA is induced rapidly by focal cerebral ischemia in rats, and inhibition of the action of IL-1ra, by passive immuno-neutralization, markedly enhances ischemic damage. To our knowledge this is the first report of an action of endogenous IL-1ra in the brain. Control of IL-1ra expression or action may therefore provide a useful therapeutic strategy to limit acute neurodegeneration.

译文

Interleukin-1 (IL-1) 与慢性和急性脑神经病变有关。IL-1受体拮抗剂 (IL-1ra) 是一种天然存在的蛋白质,与IL-1受体结合而不诱导信号转导,可阻断IL-1的多种作用。IL-1ra在地方一级起作用,它也在血液中循环。我们现在报告了IL-1ra作为内源性神经保护分子在大脑中的生物学功能的证据。大鼠局灶性脑缺血可迅速诱导IL-1ra mRNA的表达,而通过被动免疫中和抑制IL-1ra的作用可显着增强缺血损伤。据我们所知,这是大脑内源性IL-1ra作用的第一份报告。因此,控制IL-1ra表达或作用可能会提供一种有用的治疗策略,以限制急性神经变性。

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