Oral administration of Shosaikoto (1.4g/kg) enhanced phagocytosis of casein-induced murine peritoneal macrophages and nitric oxide (NO) production of thioglycilate broth-induced murine peritoneal macrophages. To clarify the kind of compounds are responsible for this augmentation of macrophage function, ethanol-precipitation was carried out to produce two fractions: one of ethanol-precipitates (EP) and one ethanol-soluble (ES). The EP fraction consisted of polysaccharide and showed enhancement of phagocytosis and NO production comparable to Shosaikoto's. On the other hand, the ES fraction consisted of low molecular compounds and did not affect macrophage function. These results suggest a crude polysaccharide fraction plays an important role in Shosaikoto's macrophage activation.

译文

:Shosaikoto(1.4g / kg)的口服增强酪蛋白诱导的鼠腹膜巨噬细胞的吞噬作用和硫代乙醇酸盐肉汤诱导的鼠腹膜巨噬细胞的一氧化氮(NO)产生。为了弄清负责增强巨噬细胞功能的化合物的种类,进行了乙醇沉淀,产生了两个馏分:一个乙醇沉淀(EP)和一个乙醇可溶(ES)。 EP级分由多糖组成,与Shosaikoto相比具有吞噬作用和NO产生增强作用。另一方面,ES级分由低分子化合物组成,不影响巨噬细胞功能。这些结果表明,粗多糖部分在Shosaikoto的巨噬细胞活化中起着重要作用。

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