The bronchodilator activity of an aqueous fraction (AF) of a 70% hydroalcoholic extract of the leaves of Cissampelos sympodialis Eichl. was evaluated in the guinea-pig. The AF inhibited the spontaneous tone of the trachea (IC(50), 13.9 μg/ml), which was potentiated (IC(50), 4.6 μg/ml) by 3-isobutyl-l-methylxanthine, blocked by β(2) adrenoceptor blocking agent timolol, but unaffected by removal of epithelium or addition of NG-Nitro-L-arginine methyl ester or methylene blue. The AF also antagonized contractions induced by carbachol, capsaicin and arachidonic acid in normal trachea and by ovalbumin in trachea obtained from sensitized guinea-pigs. The IC(50)-values in these experiments varied from 34.1-70.5 μg/ml. Further, the AF (100 mg/kg) by the more effective i.p. route increased the preconvulsive time of animals exposed to an aerosol of histamine to 63.5 ± 5 s 1 h after administration compared to 28 ± 1 s in the untreated group. In addition, the AF at 100 mg/kg i.p. or i.G. protected the sensitized guinea-pigs against anaphylactic shock induced by ovalbumin aerosol by 78.6 and 86.7% respectively.

译文

:七叶蝉叶的70%的水醇提取物的水相(AF)的支气管扩张活性。在豚鼠中进行了评估。 AF抑制了气管的自发音调(IC(50),13.9μg/ ml),其被3-异丁基-1-甲基黄嘌呤(β(2)阻断)增强了(IC(50),4.6μg/ ml)。肾上腺素受体阻滞剂噻吗洛尔,但不受上皮去除或添加NG-硝基-L-精氨酸甲酯或亚甲基蓝的影响。房颤还拮抗正常气管中卡巴胆碱,辣椒素和花生四烯酸引起的收缩,以及从致敏的豚鼠获得的气管中卵清蛋白引起的收缩。这些实验中的IC(50)值从34.1-70.5μg/ ml不等。此外,AF(100 mg / kg)的腹腔镜效果更佳。给药后1小时,暴露于组胺气溶胶的动物的惊厥前时间延长至63.5±5 s,而未治疗组为28±1 s。此外,AF的i.p.为100 mg / kg。或i.G.致敏豚鼠对卵白蛋白气溶胶引起的过敏性休克的保护作用分别为78.6和86.7%。

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