Background Reports on sex differences in stroke outcome and risk factors are scarce in Latin America. Our objective was to analyze clinical and prognostic differences according to sex among participants in the LASE (Latin American Stroke Registry). Methods and Results Nineteen centers across Central and South America compiled data on demographics, vascular risk factors, clinical stroke description, ancillary tests, and functional outcomes at short-term follow-up of patients included from January 2012 to January 2017. For the present study, all these variables were analyzed according to sex at hospital discharge. We included 4788 patients with a median in-hospital stay of 8 days (interquartile range, 5-8); 2677 were male (median age, 66 years) and 2111 female (median age, 60 years). Ischemic stroke occurred in 4293: 3686 as cerebral infarction (77%) and 607 as transient ischemic attack cases (12.7%); 495 patients (10.3%) corresponded to intracerebral hemorrhage. Poor functional outcome (modified Rankin scale, 3-6) was present in 1662 (34.7%) patients and 38.2% of women (P<0.001). Mortality was present in 6.8% of the registry, with 7.8% in women compared with 6.0% in men (P=0.01). Death and poor functional outcome for all-type stroke showed a higher risk in female patients (hazard ratio, 1.3, P=0.03; and hazard ratio, 1.1, P=0.001, respectively). Conclusions A worse functional outcome and higher mortality rates occurred in women compared with men in the LASE, confirming sex differences issues at short-term follow-up.

译文

:在拉丁美洲,关于中风结局和危险因素的性别差异的报道很少。我们的目标是根据LASE(拉丁美洲中风注册中心)参与者的性别分析临床和预后差异。方法和结果从2012年1月至2017年1月,在短期随访中,中美洲和南美洲的19个中心收集了有关人口统计学,血管危险因素,临床中风描述,辅助检查和功能结局的数据。 ,所有这些变量都根据出院时的性别进行了分析。我们纳入了4788名患者的中位住院天数为8天(四分位间距为5-8);男性2677岁(中位年龄66岁),女性2111岁(中位年龄60岁)。缺血性中风发生在4293:3686例为脑梗死(77%)和607例为短暂性脑缺血发作病例(12.7%); 495例(10.3%)对应于脑出血。 1662名患者(34.7%)和女性的38.2%的患者存在功能不良的结果(改良的Rankin评分,3-6)。死亡率为6.8%,女性为7.8%,男性为6.0%(P = 0.01)。所有类型中风的死亡和较差的功能预后均显示女性患者较高的风险(危险比为1.3,P = 0.03;危险比为1.1,P = 0.001)。结论在LASE中,与男性相比,女性的功能结局更差,死亡率更高,这证实了短期随访中的性别差异问题。

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