OBJECTIVE:Studies have reported that up to 60% of individuals with schizophrenia are overweight or obese. This study explored the relationship between obesity and health-related quality of life (HRQoL) in Chinese patients with schizophrenia. METHODS:A total of 1,108 patients with schizophrenia aged 18-50 years were recruited from 10 different sites in China. Demographic and medical information were collected; the Mandarin version of Short Form 36 Health Survey questionnaire (SF-36) was used to assess HRQoL; in addition,height and weight were measured to calculate body mass index (BMI). BMI was categorized into underweight, normal weight, overweight and obese using cutoffs for Asian populations recommended by the World Health Organization. RESULTS:Fifty-six percent of participants with schizophrenia were overweight or obese. A higher BMI was associated with significantly lower scores in physical functioning, role-physical, and physical component summary (p's ≤ 0.010). Obese patients with schizophrenia had significantly lower scores in 3 domains and physical component summary of the SF-36 compared with normal weight patients (p's ≤ 0.007). CONCLUSION:Obesity is associated with decreased HRQoL in Chinese patients with schizophrenia. Our findings suggest that the prevention and management of weight gain and obesity is important in improving HRQoL in patients who suffer from this devastating mental illness.

译文

目的:研究报告称,多达60%的精神分裂症患者超重或肥胖。这项研究探讨了肥胖与中国精神分裂症患者健康相关生活质量(HRQoL)之间的关系。
方法:从中国10个不同地区招募了1108名18至50岁的精神分裂症患者。收集了人口和医疗信息;简短的36号健康调查问卷的中文版(SF-36)用于评估HRQoL;另外,测量身高和体重以计算体重指数(BMI)。根据世界卫生组织(WHO)推荐的针对亚洲人群的临界值,将BMI分为体重过轻,正常体重,超重和肥胖。
结果:精神分裂症参与者中有56%是超重或肥胖。较高的BMI与身体机能,角色-身体和身体组成部分摘要中的得分明显较低有关(p≤0.010)。与正常体重的患者相比,肥胖的精神分裂症患者在3个领域和SF-36的物理成分摘要方面得分明显较低(p≤0.007)。
结论:肥胖与中国精神分裂症患者的HRQoL降低有关。我们的研究结果表明,预防和控制体重增加和肥胖对改善患有这种毁灭性精神疾病的患者的HRQoL很重要。

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