BACKGROUND/OBJECTIVES:Previous studies in Gambian women with a low calcium intake have described decreases in whole-body and regional bone mineral content (BMC) and areal bone mineral density (aBMD) during the first year of lactation. The aim of this study was to examine whether these effects are reversed after lactation. SUBJECTS/METHODS:Thirty-three Gambian women who had a previous dual-energy X-ray absorptiometry (DXA) scan at 52 weeks lactation (L52) were invited to participate in a follow-up study when neither pregnant nor lactating (NPNL) for ≥3 months and/or when 52 weeks postpartum in a subsequent lactation (F52). Whole body, lumbar spine and hip bone mineral were measured by DXA. Anthropometry and dietary assessments were also conducted. Repeated-measures analysis of covariance was used to determine differences from L52 at NPNL and F52. RESULTS:Twenty-eight women were scanned at NPNL and 20 at F52. The mean±s.d. calcium intake of the 33 women at NPNL and F52 was 360±168 mg/day. BMC, aBMD and size-adjusted BMC (SA-BMC) at all sites were higher at NPNL than L52. Percent increases in SA-BMC (mean±s.e.m.) were significant (P<0.0001): whole body=2.7±0.4%; lumbar spine=4.9±1.0%; total hip=3.7±1.0%. There were no significant differences in any measurements between the two lactation time points (L52 and F52). CONCLUSIONS:This study of Gambian women with low calcium intakes demonstrates that bone mineral mobilised during lactation is recovered after lactation. Successive periods of long lactation are not associated with progressive skeletal depletion.

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背景/目的:先前对低钙摄入量的冈比亚妇女进行的研究表明,哺乳第一年期间,全身和区域性骨矿物质含量(BMC)和面骨矿物质密度(aBMD)下降。这项研究的目的是检查哺乳后这些作用是否被逆转。
受试者/方法:33名在哺乳期52周(L52)进行过双能X线吸收法(DXA)扫描的冈比亚妇女,被邀请参加既未妊娠又未哺乳(NPNL)的随访研究。 ≥3个月和/或产后52周,随后泌乳(F52)。通过DXA测量全身,腰椎和髋骨矿物质。还进行了人体测量和饮食评估。协方差的重复测量分析用于确定与NPNL和F52处的L52的差异。
结果:28名妇女在NPNL进行了扫描,而20名在F52进行了扫描。平均值±s.d。在NPNL和F52处的33名妇女的钙摄入量为360±168 mg /天。在NPNL,所有地点的BMC,aBMD和尺寸调整后的BMC(S​​A-BMC)均高于L52。 SA-BMC的增加百分比(平均值±s.e.m。)显着(P <0.0001):全身= 2.7±0.4%;腰椎= 4.9±1.0%;总髋关节= 3.7±1.0%。在两个泌乳时间点(L52和F52)之间的任何测量结果均无显着差异。
结论:这项对低钙摄入量的冈比亚妇女的研究表明,哺乳期动员的骨矿物质在哺乳后可以恢复。长期哺乳的连续时期与进行性骨骼耗竭无关。

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