OBJECTIVE:To assess and compare immediate effects of chest physiotherapy with positive expiratory pressure (PEP) versus oscillating PEP on transcutaneously measured blood-gas tensions in patients with cystic fibrosis. METHODS:Fifteen patients (mean age 12.5 y, range 6.9-21.5 y) participated. The treatments were randomized and performed on 2 separate occasions, 8 weeks apart. Spirometry was conducted before and after each treatment. We transcutaneously measured oxygen tension (P(tO2). RESULTS:There were no changes in spirometry values. During PEP, different trends in blood-gas tension were seen, and there were no consistent changes. During oscillating PEP, P(tO2) increased and P(tCO2) decreased. During oscillating PEP, P(tCO2) was lower and the intra-individual change in P(tCO2) was more pronounced than during PEP. The results obtained immediately after oscillating PEP showed a higher P(tO2) and a lower P(tCO2) than with PEP. CONCLUSION:PEP and oscillating PEP can both cause transitory effects on blood gases in patients with cystic fibrosis. However, oscillating PEP alters blood-gas tensions more than does PEP, and hyperventilation during oscillating PEP may reduce treatment time.

译文

目的:评估和比较呼气正压(PEP)和振荡PEP对胸部物理治疗对囊性纤维化患者经皮测量的血气张力的即时效果。
方法:15例患者(平均年龄12.5岁,范围6.9-21.5岁)参加了研究。治疗是随机的,分别在两个不同的场合进行,相隔8周。在每次治疗之前和之后进行肺活量测定。我们经皮测量了氧气张力(P(tO2)。
结果:肺活量测定值没有变化。在PEP期间,观察到了血气紧张的不同趋势,并且没有一致的变化。在振荡PEP期间,P(tO2)增加而P(tCO2)减少。在振荡PEP期间,P(tCO2)较低,并且P(tCO2)的内部个体变化比PEP期间更为明显。振荡PEP后立即获得的结果显示,与PEP相比,P(tO2)更高,P(tCO2)更低。
结论:PEP和振荡PEP均可对囊性纤维化患者的血气产生短暂影响。但是,与PEP相比,振荡PEP对血气压力的改变更大,并且在振荡PEP期间过度换气可能会减少治疗时间。

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