BACKGROUND:While the incidence of discontinuation events in controlled studies of serotonin reuptake inhibitors ranges between 34.5% and 86%, only a small number of discontinuation reactions are reported to national data bases of spontaneously reported adverse drug reactions. It was hypothesized that the disparity was due to lack of knowledge amongst physicians about the potential for antidepressant discontinuation reactions.

METHOD:Therefore, a questionnaire was mailed to 100 psychiatrists and 100 general practitioners (GPs) in northeast England to assess the knowledge base and to validate this assumption.

RESULTS:Fifty psychiatrists (50%) and 53 GPs (53%) responded to the questionnaire. Of the respondents, 36 (72%) of the psychiatrists and 16 (30%) of the GPs were aware that patients may experience antidepressant discontinuation events; 33 (66%) psychiatrists and 22 (42%) GPs had had experience with patients who had discontinuation symptoms; and 10 (20%) psychiatrists and 9 (17%) GPs said they always caution patients about the possibility of discontinuations events.

CONCLUSION:According to the results of the survey, a sizable minority of physicians denied being confidently aware of the existence of antidepressant withdrawal symptoms. Education about discontinuation reactions, including the hallmark features, symptoms, and course, is needed for both psychiatrists and family practice physicians.

译文

背景:尽管在5-羟色胺再摄取抑制剂对照研究中,停药事件的发生率在34.5%至86%之间,但自发报告的药物不良反应的国家数据库仅报告了少量停药反应。据推测,这种差异是由于医师之间对抗抑郁药终止反应潜能的了解不足。

METHOD :因此,向100名精神科医生和100名全科医生发送了问卷

结果:50名精神科医生和50名精神科医生(53%)对问卷进行了答复。在受访者中,有36名(72%)的精神科医生和16名(30%)的全科医生知道患者可能会经历抗抑郁药停药事件; 33名(66%)精神科医生和22名(42%)GPs曾有中止症状患者的经验;和10(20%)的精神科医生和9(17%)的GP表示,他们总是提醒患者有关停药事件的可能性。

结论:根据调查结果,少数医师否认自信地知道抗抑郁药戒断症状的存在。精神科医生和家庭执业医生都需要接受有关终止反应的教育,包括标志性特征,症状和病程。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录