Patients undergoing total knee replacement for end stage knee osteoarthritis (OA) become increasingly younger and more demanding. Consequently, outcome assessment tools need to evolve toward objective performance-based measures. We applied a novel approach toward ambulatory biomechanical assessment of physical function using a single inertial sensor located at the pelvis to derive various motion parameters during activities of daily living. We investigated the potential of a clinically feasible battery of tests to define relevant parameters of physical function. We compared preoperative measures of end stage knee OA patients to healthy subjects. Our results show that measures of time yield the highest discriminative capacity to differentiate between groups. Additionally we found disease-dependent and task-specific alterations of movement for inertial sensor-derived motion parameters with good discriminative capacity. The inertial sensor's output quantities seem to capture another clinically relevant dimension of physical function that is supplementary to time. This study demonstrates the potential of inertial sensor-based motion analysis and provides a standardized test feasible for a routine clinical application in the longitudinal follow-up.

译文

:正在接受全膝关节置换以治疗终末期膝骨关节炎(OA)的患者变得越来越年轻,要求也越来越高。因此,结果评估工具需要朝着基于绩效的客观指标发展。我们使用位于骨盆的单个惯性传感器对运动功能进行动态生物力学评估的新方法,以在日常生活活动中得出各种运动参数。我们研究了临床上可行的一系列测试的潜力,以定义相关的身体机能参数。我们比较了晚期膝骨关节炎患者与健康受试者的术前措施。我们的结果表明,时间量度具有最高的区分人群的区分能力。此外,我们发现了惯性传感器衍生的运动参数具有良好的判别能力的疾病相关和任务特定的运动变化。惯性传感器的输出量似乎捕获了另一项与临床相关的物理功能,是对时间的补充。这项研究证明了基于惯性传感器的运动分析的潜力,并为纵向随访中的常规临床应用提供了可行的标准化测试方法。

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