Mononuclear complexes [Cu(Itpy)X(H2O)]X (Itpy--imidazole terpyridine, X--NO3 1 and X--ClO4 2) have been synthesized and characterized. Single crystal X-ray diffraction of complex 1 shows distorted octahedral geometry around the copper (II) ion. Presence of multiple hydrogen bonding network in the molecule results in anti-parallel stacking of the molecule. Both the complexes show dual mode of binding to DNA. Both the complexes have been found to bring about DNA cleavage in the presence of H2O2 and show potent cytotoxicity towards lung carcinoma cell line. The ability of the two complexes to induce apoptosis has been investigated by using combination of nuclear stains. FACS analysis shows that both the complexes bring about cell cycle arrest at 2.5 μM concentration.

译文

:已经合成并表征了单核络合物[Cu(Itpy)X(H2O)] X(Itpy-咪唑联吡啶,X-NO3 1和X-ClO4 2)。配合物1的单晶X射线衍射显示铜(II)离子周围的八面体几何形状失真。分子中存在多个氢键网络会导致分子反平行堆积。两种复合物均显示出与DNA结合的双重模式。已经发现两种复合物在H 2 O 2存在下引起DNA切割,并且显示出对肺癌细胞系的有效细胞毒性。通过使用核染色剂的组合已经研究了两种复合物诱导凋亡的能力。 FACS分析表明,两种复合物均以2.5μM的浓度引起细胞周期停滞。

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