The present work describes the formulation and evaluation of the gastroretentive system of Itopride hydrochloride. In this research, we have formulated floating hydrogel-based microspheres employing calcium carbonate (CaCO(3)) as a gas forming agent dispersed in alginate matrix. In vitro characterizations such as drug content, particle size, and drug release were carried out. GI motility was determined by administration of charcoal meal to rats. Results demonstrated that prepared microspheres were spherical in shape with smooth surface, good loading efficiency, and excellent buoyancy. The gastro retentive dosage form of itiopride demonstrated significant antacid, anti-ulcer, and anti-GERD activity after 12 hours in comparison with the conventional dosage form.

译文

:本工作描述了盐酸依托必利胃滞留系统的配方和评估。在这项研究中,我们制定了浮动的基于水凝胶的微球,使用碳酸钙(CaCO(3))作为分散在藻酸盐基质中的气体形成剂。进行了体外表征,例如药物含量,粒径和药物释放。通过向大鼠施用木炭粉确定胃肠动力。结果表明,制备的微球为球形,表面光滑,加载效率好,浮力好。与常规剂型相比,依托必利的胃滞留剂型在12小时后显示出显着的抗酸,抗溃疡和抗GERD活性。

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