The aim of this paper was to define, for the first time in Italy, normal levels of total serum IgE in a general population sample of North Italy. Total serum IgE in 1905 subjects, living in Po Delta area (near Venice), were measured by PRIST method. Normal values were derived from 558 subjects without asthma and/or asthmatic/rhinitic symptoms, noncurrent smokers, skin prick-test negatives ('normals'). Cut-off values to differentiate 'normals' from the remaining part of the sample ('others'), from asthmatic, and from rhinitic subjects, were established with the IgE value midway between the upper limit of the 95% confidence intervals (CI) of the geometric mean for 'normals' and the lower limit for 'others', asthmatics, and rhinitics, respectively. Geometric mean of normal children-adolescents was 45 kU/L (SD: 2.6; 95% CI: 38-63). In normal adults geometric mean was 29 kU/L (SD: 3.3; 95% CI: 25-40) in males and 19 kU/L (SD: 3.8; 95% CI: 16-22) in females. The diagnostic sensitivity of IgE test was low, while the specificity was very high. A good positive predictive value in discriminating 'normals' from 'others' was found, on the contrary, we found a good negative predictive value in discriminating 'normals' from asthmatics or from rhinitics. In conclusion, our results confirm that it is necessary to provide separate total serum IgE reference values for what concerns age in children-adolescents and in adults, and gender, in adults. Low serum IgE are helpful to exclude allergic asthma or rhinitis level of total.

译文

:本文的目的是首次确定意大利北部普通人群中总血清IgE的正常水平。通过PRIST方法测量了居住在Po Delta地区(威尼斯附近)的1905名受试者的总血清IgE。正常值来自558名无哮喘和/或哮喘/鼻炎症状,无烟民,皮肤点刺试验阴性的受试者(“正常”)。在IgE值介于95%置信区间(CI)上限之间的中间位置时,建立了区分“正常”值与样本其余部分(“其他”值),哮喘对象和鼻炎对象的临界值。 “常态”的几何平均值的平均值和“其他”,哮喘和鼻炎的下限的平均值。正常儿童-青少年的几何平均值为45 kU / L(标准差:2.6; 95%CI:38-63)。在正常成年人中,男性的几何平均值为29 kU / L(SD:3.3; 95%CI:25-40),女性为19 kU / L(SD:3.8; 95%CI:16-22)。 IgE测试的诊断敏感性较低,而特异性却很高。相反,我们发现在区分“正常人”与“其他人”方面具有良好的阳性预测价值,相反,我们发现在区分“正常人”与哮喘或鼻炎方面具有良好的阴性预测价值。总之,我们的结果证实,有必要针对儿童,青少年和成人的年龄以及成人的性别提供单独的总血清IgE参考值。较低的血清IgE有助于排除总的过敏性哮喘或鼻炎水平。

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