BACKGROUND:COVID-19 has rapidly spread worldwide, with severe complications affecting particularly elderly and compromised subjects. Less information about COVID-19 in pregnancy has been reported so far in the literature. METHODS:Case series on pregnancies complicated by COVID-19. All cases were diagnosed at Bolognini Hospital, Seriate, Italy. These cases are presented to clarify the features of COVID-19 occurring in pregnancy. RESULTS:Four women had symptoms of COVID-19 during pregnancy or immediately after delivery. All cases were confirmed by oropharyngeal swab. All patients presented with fever and low saturation levels at the diagnosis. One case was transferred after diagnosis to a tertiary referral center and delivered the day after for worsening clinical conditions. In the other three cases, bilateral pneumonia was documented at the admission. Antithrombotic therapy was used in most cases. No cases of the infected neonate was reported. At 2 month follow-up, all patients were alive, three were asymptomatic while one presented neurological complication. One more case was described because suspicious for COVID-19, however, it was not confirmed by oropharyngeal swab. CONCLUSIONS:In pregnant women, the peripheral nervous system could be affected. No case of trans-placental passage was reported. The swab could be helpful in diagnosis. The antithrombotic therapy could play a role in the positive course of COVID-19 also in pregnant women.

译文

背景:COVID-19已在世界范围内迅速传播,严重并发症严重影响了老年人和弱势人群。迄今为止,文献中报道的妊娠COVID-19信息较少。
方法:病例并发妊娠合并COVID-19的病例。所有病例均在意大利塞里特的博洛尼尼医院诊断。提出这些病例是为了阐明孕妇中发生的COVID-19的特征。
结果:四名妇女在怀孕期间或分娩后立即出现COVID-19症状。所有病例均经口咽拭子确诊。所有患者在诊断时均出现发烧和低饱和度水平。一例确诊后被转移到三级转诊中心,并于次日因临床情况恶化而分娩。在其他三例中,入院时记录有双侧肺炎。大多数情况下使用抗血栓治疗。没有报道感染新生儿的病例。随访2个月,所有患者均存活,其中3例无症状,其中1例出现神经系统并发症。由于对COVID-19可疑,还描述了另外一例,但尚未通过口咽拭子确认。
结论:在孕妇中,外周神经系统可能受到影响。没有报道经胎盘通过的病例。拭子可能有助于诊断。抗血栓治疗也可能在孕妇的COVID-19阳性过程中发挥作用。

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