AIM:To determine whether concomitant iron affects the absorption of mycophenolate mofetil. METHODS:An open-label, single centre, randomized, crossover trial was conducted in 16 healthy males. Fasting subjects received mycophenolate mofetil alone (treatment A) or co-administered with iron (treatment B). RESULTS:The mycophenolic acid AUC(0,24 h) for treatments A and B were 42.5 +/- 10.5 and 44.7 +/- 12.4 microg ml(-1) h, respectively. anova modelling showed the relative bioavailability of mycophenolate mofetil to be similar for the two treatments (90% confidence interval 0.92, 1.19). CONCLUSIONS:There was no interaction between mycophenolate mofetil and iron supplements administered concomitantly to healthy fasting subjects.

译文

目的:确定伴随的铁是否影响霉酚酸酯的吸收。
方法:对16名健康男性进行了开放标签,单中心,随机,交叉试验。空腹受试者单独接受霉酚酸酯(治疗A)或与铁合用(治疗B)。
结果:处理A和B的霉酚酸AUC(0,24 h)分别为42.5 /-10.5和44.7 /-12.4 microg ml(-1)h。方差分析建模显示,两种处理的霉酚酸酯的相对生物利用度相似(90%置信区间为0.92、1.19)。
结论:麦考酚酸酯与健康禁食对象同时服用铁补充剂之间没有相互作用。

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