Iron is an essential trace-element for most organisms. However, because high concentration of free intracellular iron is cytotoxic, cells have developed complex regulatory networks that keep free intracellular iron concentration at optimal range, allowing the incorporation of the metal into iron-using enzymes and minimizing damage to the cell. We built a mathematical model of the network that controls iron uptake and usage in the bacterium Escherichia coli to explore the dynamics of iron flow. We simulate the effect of sudden decrease or increase in the extracellular iron level on intracellular iron distribution. Based on the results of simulations we discuss the possible roles of the small RNA RyhB and the Fe-S cluster assembly systems in the optimal redistribution of iron flows. We suggest that Fe-S cluster assembly is crucial to prevent the accumulation of toxic levels of free intracellular iron when the environment suddenly becomes iron rich.

译文

铁是大多数生物必不可少的微量元素。但是,由于高浓度的游离细胞内铁具有细胞毒性,因此细胞已开发出复杂的调节网络,可将游离细胞内铁的浓度保持在最佳范围,从而将金属掺入使用铁的酶中,并将对细胞的损害降至最低。我们建立了控制该细菌大肠杆菌中铁的吸收和使用的网络数学模型,以探索铁流量的动态变化。我们模拟了细胞外铁水平突然降低或增加对细胞内铁分布的影响。基于模拟的结果,我们讨论了小RNA RyhB和Fe-S簇组装系统在铁流的最佳重新分配中的可能作用。我们建议,当环境突然变得富含铁时,Fe-S簇组装对于防止游离细胞内铁的毒性水平的积累至关重要。

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