Brief exposure to moderate intensity static magnetic fields has been shown to produce a transient alteration in physiological function in a variety of biological systems, primarily those related to changes in intracellular Ca(2+). In the present study GH3 cells were cultured during continuous exposure to a 0.5 T field, for periods of up to 5 weeks. Following a 1-week exposure, cell growth declined by 22% and returned to control levels in 1 week. This was not statistically significant but, with a 4-week exposure, a statistically significant decline in growth of 51% was observed and return to control levels did not occur for 4 weeks. Cell diameter, on the other hand, significantly increased following 3 weeks of exposure and did not return to control levels for 3 weeks after termination of exposure. Ca(2+)-dependent changes in the dynamic reorganization of the actin cytoskeleton are suggested as the probable explanation for these observations.

译文

:短暂暴露于中等强度的静磁场已显示在多种生物系统中,主要是与细胞内Ca(2)的变化有关的生理功能中,产生暂时性的生理变化。在本研究中,在连续暴露于0.5 T场的过程中培养GH3细胞长达5周。暴露1周后,细胞生长下降了22%,并在1周内恢复到对照水平。这在统计学上不显着,但是在暴露4周后,观察到生长增长在统计学上显着下降51%,并且在4周内未出现恢复到对照水平的情况。另一方面,细胞直径在接触3周后显着增加,并且在接触终止后3周未恢复到对照水平。 Ca(2)依赖变化的肌动蛋白细胞骨架的动态重组被建议为这些观察结果的解释。

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