OBJECTIVE:Bone loss and periosteal expansion is found after menopause. The accelerated early postmenopausal bone loss is not permanent but if the same accounts for the periosteal expansion is unknown. METHODS:Bone mineral density (BMD) and skeletal structure of the distal forearm were followed from menopause and on average 24 years (range 18-28) by single-photon absorptiometry at 12 occasions in a population-based sample of 81 Caucasian women with no medication or disease affecting bone metabolism. A Strength Index based on areal BMD and bone structure was calculated. Postmenopausal serum-estradiol levels and incident distal radius fractures were registered. Data are presented as means with 95% confidence interval (95% CI). RESULTS:The annual BMD loss in three periods, 0-8, 8-16 and 16-28 years after menopause, was 2.0% (1.6, 2.4), 1.0% (0.6, 1.4) and 1.0% (0.7, 1.3), respectively. The annual periosteal expansion was 1.0% (0.8, 1.3), 0.0% (-0.3, 0.3) and 0.0% (-0.2, 0.2), respectively. Mean post-menopausal oestrogen levels correlated moderately with annual loss in aBMD (r=0.51, p<0.001) but less with the annual changes in bone width (r= -0.22, p=0.06). CONCLUSION:Postmenopausal periosteal expansion in the distal forearm seems to occur only in the first postmenopausal decade.

译文

目的:更年期后发现骨丢失和骨膜扩张。绝经后早期加速的骨丢失不是永久性的,但未知是否导致骨膜扩张。
方法:采用单光子吸光光度法,在81例白人女性中,从更年期开始追踪平均绝经后平均24年(18-28岁)的骨矿物质密度(BMD)和平均年龄(18-28)。影响骨骼代谢的药物或疾病。计算出基于面积骨密度和骨骼结构的强度指数。记录绝经后血清雌二醇水平和incident骨远端骨折的发生率。数据以具有95%置信区间(95%CI)的平均值表示。
结果:绝经后0-8、8-16和16-28年这三个时期的年BMD损失分别为2.0%(1.6、2.4),1.0%(0.6、1.4)和1.0%(0.7、1.3),分别。每年的骨膜扩张分别为1.0%(0.8,1.3),0.0%(-0.3,0.3)和0.0%(-0.2,0.2)。绝经后的平均雌激素水平与aBMD的年度损失呈中等程度的相关性(r = 0.51,p <0.001),而与年度骨宽变化的相关性较小(r = -0.22,p = 0.06)。
结论:绝经后前臂远端的骨膜扩张似乎仅发生在绝经后的第一个十年中。

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