Results from pharmacogenetic investigations of methylphenidate (MPH) response in patients with ADHD are still inconsistent, especially among adults. This study investigates the role of genetic variants (SLC6A4, HTR1B, TPH2, DBH, DRD4, COMT, and SNAP25) in the response to MPH in a sample of 164 adults. Genes were chosen owing to previous evidence for an influence in ADHD susceptibility. No significant differences in allele or genotype frequencies between MPH responders and nonresponders were detected. In conclusion, our findings do not support an effect of these genes in the pharmacogenetics of MPH among adults with ADHD.

译文

多动症患者中哌醋甲酯 (MPH) 反应的药物遗传学研究结果仍然不一致,尤其是在成年人中。这项研究调查了164名成年人样本中遗传变异 (SLC6A4,HTR1B,TPH2,DBH,DRD4,COMT和SNAP25) 对MPH反应的作用。由于先前的证据对ADHD易感性有影响,因此选择了基因。在MPH应答者和非应答者之间未检测到等位基因或基因型频率的显着差异。总之,我们的发现不支持这些基因在ADHD成人中MPH的药物遗传学中的作用。

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