OBJECTIVE:The goal of this study was to develop an improved (62)Zn/(62)Cu generator based on cation exchange resin and remote preparation at high radioactivity scale for clinical use. METHODS:A natural Cu target was irradiated with proton beam in the energy range of 30-->19 MeV at a beam current of 10 muA for 1 h to obtain around 1.7 GBq of (62)Zn. The (62)Zn was isolated from the Cu target on an anion exchange column with more than 97% yield within 2.5 h from the EOB. The (62)Zn/(62)Cu generator was prepared by loading the (62)Zn(2+) on a Sep-Pak plus CM cartridge. RESULTS:The generator showed high elution efficiency ( approximately 96%) using a small volume (ca. 3 ml) of a 200-mM glycine solution with a very low breakthrough of (62)Zn (<0.1%). CONCLUSIONS:This (62)Zn/(62)Cu generator has been proven to be highly useful as a source of (62)Cu for the synthesis of (62)Cu-labeled compounds. The clinical application of [(62)Cu]Cu-ATSM produced with this generator has been already approved by the Institutional Review Board at the National Institute of Radiological Sciences.

译文

目的:本研究的目的是开发一种改进的(62)Zn /(62)Cu生成器,该生成器基于阳离子交换树脂和高放射性规模的远程制备方法,可用于临床。
方法:在能量范围为30-> 19 MeV的质子束中,以10μA的束流对天然Cu靶辐照1 h,以获得约1.7 GBq的(62)Zn。从EOB到2.5 h内,从阴离子交换柱上的Cu靶中分离出(62)Zn。通过将(62)Zn(2)加载到Sep-Pak plus CM滤芯上来制备(62)Zn /(62)Cu发生器。
结果:使用少量(约3 ml)的200 mM甘氨酸溶液,生成器显示出较高的洗脱效率(约96%),其中(62)Zn的穿透率极低(<0.1%)。
结论:该(62)Zn /(62)Cu生成物已被证明可高度有效地用作(62)Cu的来源,用于合成(62)Cu标记的化合物。用这种发生器产生的[(62)Cu] Cu-ATSM的临床应用已经由美国放射科学学会的机构审查委员会批准。

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