A panel of monoclonal antibodies which react with empty non-infectious type 3 poliovirus particles (C antigen) but not infectious virus (D antigen) were characterized for their reactivity with C antigen particles derived from neutralization-resistant virus strains which had single amino acid substitutions at each of the antigenic sites. Antibodies were identified which failed to bind to variant viruses with modifications at each of antigenic sites 2b, 3b and 4 indicating that the same amino acid sequences involved in the neutralization of infectious virus are also present on the surface of non-infectious particles but in different configurations.

译文

:一组与空的非感染性3型脊髓灰质炎病毒颗粒(C抗原)但不与感染性病毒(D抗原)发生反应的单克隆抗体,其与衍生自具有单个氨基酸的中和抗性病毒株的C抗原颗粒的反应性得到了表征每个抗原位点的取代。鉴定了未能结合在抗原性位点2b,3b和4处被修饰的变异病毒的抗体,这表明与感染性病毒的中和有关的相同氨基酸序列也存在于非感染性颗粒的表面,但存在差异配置。

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