The effect of lentinan administration on monocyte function in the peripheral blood were examined in 33 patients who underwent resection of gastric cancer. As parameters of monocyte function, IL-1 production, C3b receptor, Fc gamma receptor and monocyte ratio were determined every 4 weeks for a maximum of 24 weeks. Among patients who were taking combined therapy with lentinan, an increase in IL-1 beta production of more than 50% was found 8 weeks (2 months) after the initiation of therapy in 8 of 12 patients given 2 mg at 2-week intervals, and in 11 of 16 patients given the same dose at 4-week intervals. This increase was particularly clear in stage II or more advanced cases. There were no significant changes in the other parameters studied. It has been considered that lentinen is effective when administered once a week. The results of the present study, however, suggest that lentinan given every 4 weeks also stimulates monocyte function enough to maintain immunological activity.

译文

在33例接受胃癌切除的患者中检查了香菇多糖对外周血单核细胞功能的影响。作为单核细胞功能的参数,每4周测定一次IL-1的产生,C3b受体,Fcγ受体和单核细胞的比例,最多24周。在开始使用香豆素联合治疗的患者中,在开始治疗后8周(2个月),每12周给予2 mg的12例患者中有8例的IL-1β产生增加了50%以上,在16名患者中,有11名患者每隔4周服用相同剂量。在第二阶段或更晚期的病例中,这种增加尤为明显。研究的其他参数没有显着变化。人们认为,香菇素每周一次给药是有效的。但是,本研究的结果表明,每4周给予一次香菇多糖也能刺激单核细胞功能,足以维持免疫活性。

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