Our work aimed to examine the potential influence of variants in interleukin/interleukin receptors genes on high-risk (HR-HPV) HPV clearance. Clearance of genital HR-HPV infection was evaluated for 134 HIV-1 seropositive African-American female adolescents from the Reaching for Excellence in Adolescent Care and Health (REACH) cohort. Genotyping targeted 225 single nucleotide polymorphisms (SNPs) within the exons, 5' untranslated region (UTR) and 3' UTR sequences of 27 immune-related candidate genes encoding interleukin family of cytokines. Cox proportional hazard models were used to determine the association of type-specific HPV clearance adjusting for time-varying CD4+ T-cell count and low-risk (LR-HPV) HPV co-infections. HR-HPV clearance rates were significantly (p < 0.001) associated with five SNPs (rs228942, rs419598, rs315950, rs7737000, and rs9292618) mapped to coding and regulatory regions in three genes (IL2RB, IL1RN, and IL7R). These data suggest that the analyzed genetic variants in interleukin family of cytokines modulate HR-HPV clearance in HIV-1 seropositive African-Americans that warrants replication.
-
【Variants in interleukin family of cytokines genes influence clearance of high risk HPV in HIV-1 coinfected African-American adolescents.].
【白细胞介素细胞因子基因家族的变异会影响HIV-1合并感染的非裔美国青少年中高危HPV的清除率。】
复制标题
收藏
DOI：10.1016/j.humimm.2013.08.010文章类型：杂志文章
复制DOI
译文
：我们的工作旨在研究白介素/白介素受体基因变异对高危（HR-HPV）HPV清除的潜在影响。从“青少年护理和健康卓越计划”（REACH）队列中，对134名HIV-1血清反应阳性的非洲裔美国女性青少年的生殖器HR-HPV感染清除率进行了评估。基因分型靶向外显子内的225个单核苷酸多态性（SNP），编码细胞因子白介素家族的27个免疫相关候选基因的5'非翻译区（UTR）和3'UTR序列。使用Cox比例风险模型来确定针对随时间变化的CD4 T细胞计数和低风险（LR-HPV）HPV合并感染的类型特异性HPV清除率调整的关联。 HR-HPV清除率与五个SNPs（rs228942，rs419598，rs315950，rs7737000和rs9292618）显着相关（p <0.001），它们映射到三个基因（IL2RB，IL1RN和IL7R）的编码区和调控区。这些数据表明，分析的细胞因子白介素家族遗传变异可调节HIV-1血清反应阳性的非裔美国人的HR-HPV清除率，从而保证复制。
