BACKGROUND:Interleukin (IL)-9 drives gut inflammation, but its role in Crohn's disease (CD) is unclear. We aimed to analyze correlations between serum IL-9 levels and disease severity and to evaluate their predictive value in relation to the clinical efficacy of infliximab (IFX) in patients with CD. METHODS:Between January 2013 and December 2015, 100 consecutive patients with active CD and 50 age- and sex-matched control individuals were recruited from a tertiary center. Their serum IL-9 levels were measured using an enzyme-linked immunosorbent assay. Correlations between the serum IL-9 levels and disease severity were examined. The serum IL-9 level was explored as a predictor of clinical remission and mucosal healing at week 30 in 50 patients for whom IFX therapy was administered. RESULTS:The serum IL-9 levels were significantly higher in the patients with active CD (22.0 pg/mL) than in the control individuals (6.3 pg/mL) (P < 0.001); they differed according to disease severity (moderate-to-severe CD: 29.1 pg/mL versus mild CD: 12.9 pg/mL) (P < 0.001), and they correlated well with the clinical activity of CD. IFX lowered the serum IL-9 level in patients who achieved efficacy at week 30. The areas under the curves for the IL-9 levels at weeks 14 and 30 that could predict clinical remission and mucosal healing at week 30 were 0.803 and 0.752 and 0.746 and 0.781, respectively. CONCLUSIONS:Serum IL-9 levels correlate with disease severity and the clinical efficacy of IFX in patients with CD, and IL-9 may be a promising novel biomarker for CD monitoring.

译文

背景:白介素(IL)-9可驱动肠道炎症,但其在克罗恩病(CD)中的作用尚不清楚。我们旨在分析血清IL-9水平与疾病严重程度之间的相关性,并评估其与英夫利昔单抗(IFX)在CD患者中的临床疗效相关的预测价值。
方法:2013年1月至2015年12月,从三级中心招募了100例连续的活动性CD患者和50例年龄和性别匹配的对照个体。使用酶联免疫吸附测定法测量其血清IL-9水平。检查血清IL-9水平与疾病严重程度之间的相关性。在接受IFX治疗的50例患者中,血清IL-9水平在30周时可作为临床缓解和粘膜愈合的预测指标。
结果:活动性CD患者的血清IL-9水平显着高于对照组(6.3 pg / mL)(22.0 pg / mL)(P <0.001);它们根据疾病的严重程度而有所不同(中度至重度CD:29.1 pg / mL,轻度CD:12.9 pg / mL)(P <0.001),并且它们与CD的临床活性密切相关。 IFX降低了在30周时达到疗效的患者的血清IL-9水平。在14周和30周时可预测临床缓解和粘膜愈合的IL-9水平曲线下面积分别为0.803和0.752和0.746和0.781。
结论:血清IL-9水平与CD患者的疾病严重程度和IFX的临床疗效相关,并且IL-9可能是有前途的新型CD监测生物标志物。

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