Objectives:Drug-laboratory test interactions (DLTIs) are one of the major sources of laboratory errors. Calcium dobesilate (CaD) interference on serum creatinine testing is a widespread problem that has long been ignored in China. A national EQA-based survey was launched to investigate the current status of CaD interference on creatinine routine methods used in China and enhance the education of CaD interference in clinical laboratories. Methods:A descriptive survey was developed to characterize the status quo of Chinese laboratory professionals' cognition to CaD interference. Four of survey samples which were spiked with/without interference additive were shipped to 175 participant laboratories. The target reference values from a reference measurement procedure were compared against the results from participating laboratories to evaluate the CaD interference on serum creatinine measurements using enzymatic method or Jaffé method. Results:The lack of knowledge of DLTIs and the barriers to collect information from pharmacological and laboratory data systems had become the main problems on implementing DLTIs education in China. A significant negative influence of CaD on enzymatic method was observed regardless of measurement platforms. Jaffé method was generally free from interaction with CaD but showed poor precision and accuracy at low creatinine concentrations. Conclusions:More efforts should be made to enhance the education of DLTIs in clinical laboratories in China.

译文

目的:药物-实验室测试相互作用(DLTI)是实验室错误的主要来源之一。苯磺酸钙(CaD)对血清肌酐检测的干扰是一个普遍的问题,在中国长期以来一直被忽略。开展了一项基于全国EQA的调查,以调查CaD干扰在中国使用的肌酐常规方法的现状,并加强对临床实验室中CaD干扰的教育。
方法:进行描述性调查,以表征中国实验室专业人员对CaD干扰的认知状况。掺加或不掺入干扰添加剂的四个调查样品被运到175个参与实验室。将来自参考测量程序的目标参考值与参与实验室的结果进行比较,以评估CaD对使用酶法或Jaffé方法进行的血清肌酐测量的干扰。
结果:缺乏对DLTIs的了解以及从药理学和实验室数据系统收集信息的障碍已成为在中国实施DLTIs教育的主要问题。无论使用何种测量平台,都可以观察到CaD对酶法的显着负面影响。 Jaffé方法通常不与CaD相互作用,但在低肌酐浓度下显示出较差的精密度和准确性。
结论:应加大力度加强我国临床实验室对DLTIs的教育。

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