Known methods of testing for interference in human genetic maps are reviewed. Two aspects of interference are distinguished, numerical interference referring to the numbers of crossovers occurring and positional interference referring to the positions of crossovers. Tests for interference generally address only one or the other of these two aspects. Published investigations of interference presume fully informative marker maps, while in reality genetic markers are of limited heterozygosity, which weakens some of the tests for interference. The conclusion is drawn that rigorous tests for interference have not yet been carried out for human data.

译文

综述了检测人类遗传图谱中干扰的已知方法。区分了干扰的两个方面,数字干扰是指发生的交叉次数,位置干扰是指交叉的位置。干扰测试通常仅针对这两个方面中的一个或另一个。公开发表的对干扰的研究假定具有充分信息的标记图,而实际上,遗传标记的杂合度有限,这削弱了一些干扰测试。结论是,尚未对人类数据进行严格的干扰测试。

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