In the present pilot study, the feasibility of a site-of-care cervicovaginal self-sampling methodology for HPV-based screening was tested in 346 women residing in underserved rural areas of Northern Greece. These women provided self-collected cervicovaginal sample along with a study questionnaire. Following molecular testing, using the cobas® HPV Test, Roche®, HPV positive women, were referred to colposcopy and upon abnormal findings, to biopsy and treatment. Participation rate was 100%. Regular pap-test examination was reported for 17.1%. Among hrHPV testing, 11.9% were positive and colposcopy/biopsy revealed 2 CIN3 cases. Non-compliance was the most prevalent reason for no previous attendance. Most women reported non-difficulty and non-discomfort in self-sampling (77.6% and 82.4%, respectively). They would choose self-sampling over clinician-sampling (86.2%), and should self-sampling being available, they would test themselves more regularly (92.3%). In conclusion, self-sampling is feasible and well-accepted for HPV-based screening, and could increase population coverage in underserved areas, helping towards successful prevention.

译文

:在本项初步研究中,对希腊北部农村地区服务不足的346名妇女进行了基于宫颈癌阴道自我采样方法的HPV筛查的可行性的测试。这些妇女提供了自己收集的宫颈阴道样本以及研究问卷。在进行分子测试后,使用cobas®HPV测试,将Roche®,HPV阳性女性进行阴道镜检查,并在发现异常后进行活检和治疗。参与率为100%。定期进行子宫颈抹片检查的报道为17.1%。在hrHPV测试中,有11.9%呈阳性,阴道镜检查/活检显示有2例CIN3病例。不遵守是没有参加会议的最普遍原因。大多数妇女在自我抽样中报告没有困难和不舒服(分别为77.6%和82.4%)。他们将选择自采样而不是临床医生采样(86.2%),并且如果可以使用自采样,他们将更定期地进行自我测试(92.3%)。总之,对于基于HPV的筛查,自我抽样是可行的并且被广泛接受,并且可以扩大服务不足地区的人口覆盖率,有助于成功进行预防。

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