Some peptide hormones are associated with specific, high-affinity plasma proteins. The major binding protein (BP) for growth hormone (GH) in humans is a circulating fragment of the GH membrane receptor, consisting of the hydrophilic, extracellular portion of that transmembrane glycoprotein. The circulating levels of GH-BP mirror the levels of GH receptors. There are 4 well-characterized insulin-like growth factor (IGF)-BPs. One IGF-binding component in plasma is a fragment of the extracellular portion of the IGF-II/mannose-6-phosphate receptor, analogous to the GH-BP. The 3 other cloned IGF-BPs form a homologous family of proteins with differences in structure, glycosylation and hormonal control that suggest differences in function. The GH- and IGF-BPs play a major role in the metabolism and biological action of these peptide hormones.

译文

:某些肽激素与特定的高亲和力血浆蛋白有关。人类生长激素(GH)的主要结合蛋白(BP)是GH膜受体的循环片段,由该跨膜糖蛋白的亲水性细胞外部分组成。 GH-BP的循环水平反映了GH受体的水平。有4个特征明确的胰岛素样生长因子(IGF)-BP。血浆中的一种IGF结合成分是IGF-II /甘露糖6-磷酸受体的胞外部分的片段,类似于GH-BP。其他3个克隆的IGF-BPs形成同源的蛋白质家族,其结构,糖基化和激素控制方面存在差异,提示其功能存在差异。 GH-和IGF-BP在这些肽激素的代谢和生物学作用中起主要作用。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录