The purpose of this study is to compare the effects of spinal and epidural anesthesia on a rat transverse rectus abdominus myocutaneous flap ischemia-reperfusion injury model.Forty Sprague-Dawley rats were divided into 4 experimental groups: group I (n = 10), sham group; group II (n = 10), control group; group III (n = 10), epidural group; and group IV (n = 10), spinal group. After the elevation of the transverse rectus abdominus myocutaneous flaps, all groups except for the sham group were subjected to normothermic no-flow ischemia for 4 hours, followed by a reperfusion period of 2 hours. At the end of the reperfusion period, biochemical and histopathological evaluations were performed on tissue samples.Although there was no significant difference concerning the malonyldialdehyde, nitric oxide, and paraoxonase levels in the spinal and epidural groups, the total antioxidant state levels were significantly increased, and the total oxidative stress levels were significantly decreased in the epidural group in comparison to the spinal group. The pathological evaluation showed that findings related to inflammation, nuclear change rates and hyalinization were significantly higher in the spinal group compared with the epidural group.Epidural anesthesia can be considered as a more suitable method that enables a decrease in ischemia-reperfusion injuries in the muscle flaps.

译文

:本研究的目的是比较脊髓麻醉和硬膜外麻醉对大鼠横直肌腹肌皮瓣缺血再灌注损伤模型的影响。40只Sprague-Dawley大鼠分为4个实验组:I组(n = 10),假小组第二组(n = 10),对照组;第三组(n = 10),硬膜外组;第四组(n = 10),脊柱组。腹直肌横肌皮瓣抬高后,除假手术组外,其余各组均进行常温无血流缺血4小时,然后再灌注2小时。在再灌注期结束时,对组织样本进行了生化和组织病理学评估。尽管在脊髓和硬膜外组中丙二酰二醛,一氧化氮和对氧磷酶水平没有显着差异,但总抗氧化剂状态水平却明显升高,与硬膜外组相比,硬膜外组的总氧化应激水平显着降低。病理评估显示,与硬膜外组相比,脊髓组炎症,核变化率和透明质化相关的发现显着更高。硬膜外麻醉被认为是一种更合适的方法,可以减少肌肉的缺血再灌注损伤襟翼。

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