On May 26, 2012, the Collier County Health Department was notified by law enforcement and hospital personnel that approximately 40 persons had sought care at local emergency departments because of severe eye irritation and pain. Patients reported that they had attended a foam party at a local nightclub the night before. Syndromic surveillance activities carried out by the Florida Department of Health identified 35 patients who had visited an emergency department in Collier County on May 26 with a chief complaint related to eye injuries, well above the expected number of less than 10.