We studied 45 patients aged 14-66 years who had undergone stem cell transplantation for a variety of malignant conditions at least 12 months previously. Compared to normal controls, they had significantly reduced absolute numbers of CD4+, CD4+ CD45RA+ and CD4+ CD45RO+ T cells and a reduced CD4+ CD45RA+:CD4+ CD45RO+ ratio. In all subsets T-cell numbers were significantly greater 24 months, compared to 12-24 months, after transplantation and there was a nonsignificant trend towards lower T-cell numbers with increasing age. We conclude that the thymus, or putative thymic-equivalent tissue, remains functional in older adults.

译文

:我们研究了45位14-66岁的患者,这些患者至少在12个月前经历了各种恶性疾病的干细胞移植。与正常对照相比,他们的CD4,CD4 CD45RA和CD4 CD45RO T细胞绝对数显着降低,并且CD4 CD45RA:CD4 CD45RO比值降低。与移植后的12-24个月相比,所有亚组中的T细胞数量在24个月中均显着增加,并且随着年龄的增长,T细胞数量降低的趋势不明显。我们得出的结论是,在老年人中,胸腺或假定的胸腺等效组织仍保持功能。

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