AIMS:To evaluate the speed of onset of bronchodilation following salbutamol administered via a metered-dose inhaler with a spacer (pMDI + Volumatic) and a dry-powder inhaler (Diskus), as well as the relative potencies of these devices in asthmatic patients with methacholine-induced bronchoconstriction. METHODS:Eighteen patients inhaled methacholine (MCh) until FEV(1) decreased by 35% of control. Following administration of placebo, 200 microg salbutamol or 400 microg salbutamol through the pMDI + Volumatic or the Diskus, we calculated the time elapsed from drug administration and the appearance of a 90% increase in post-MCh forced vital capacity (FVC), FEV(1) and volume-adjusted mid-expiratory flow (recovery times). The salbutamol doses to be delivered by the two inhalation devices to achieve similar recovery times and the relative potencies of the devices were calculated by using the 2-by-2 Finney parallel regression method. RESULTS:For all functional variables, recovery times were significantly (P < 0.01) shorter in pMDI + Volumatic than Diskus trials. The salbutamol doses to be delivered by the Diskus to achieve recovery times for FVC, FEV(1) and volume-adjusted mid-expiratory flow similar to those obtained with 200 microg salbutamol administered via the pMDI + Volumatic were 558 (95% CI 537, 579) microg, 395 (95% CI 388, 404) microg and 404 (95% CI 393, 415) microg, respectively, and corresponded to relative potencies of 2.79 (95% CI 2.68, 2.90), 1.98 (95% CI 1.94, 2.02), and 2.02 (95% CI 1.96, 2.07). CONCLUSIONS:Administration of salbutamol via the pMDI + Volumatic provides faster reversal of induced bronchoconstriction than via the Diskus. The salbutamol dose targeting the lungs with the pMDI + Volumatic is approximately twice that with the Diskus.

译文

目的:评估沙丁胺醇通过带间隔垫片的定量吸入器(pMDI Volumatic)和干粉吸入器(Diskus)给药后支气管扩张的发生速度,以及这些装置在哮喘患者中使用乙酰甲胆碱的相对效力引起的支气管收缩。
方法:十八例患者吸入乙酰甲胆碱(MCh),直到FEV(1)降低至对照组的35%。通过pMDI Volumatic或Diskus给予安慰剂,200μg沙丁胺醇或400μg沙丁胺醇后,我们计算了药物给药所花费的时间以及MCh后强制肺活量(FVC),FEV(90)出现90%的增加)和经过体积调整的呼气中气流量(恢复时间)。通过使用2乘2 Finney平行回归方法计算两个吸入装置要达到相似的恢复时间所要输送的沙丁胺醇剂量,以及该装置的相对效能。
结果:对于所有功能变量,pMDI Volumatic的恢复时间比Diskus试验明显缩短(P <0.01)。与通过pMDI Volumatic施用200微克沙丁胺醇获得的FVC,FEV(1)和经体积调节的呼气中流的恢复时间相比,由Diskus输送的沙丁胺醇的剂量为558(95%CI 537,579) )微克,395(95%CI 388、404)微克和404(95%CI 393、415)微克,分别对应于2.79(95%CI 2.68、2.90),1.98(95%CI 1.94, 2.02)和2.02(95%CI 1.96,2.07)。
结论:通过pMDI Volumatic给予沙丁胺醇比通过Diskus可以更快地逆转诱导的支气管收缩。使用pMDI Volumatic靶向肺的沙丁胺醇剂量约为使用Diskus的两倍。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录