The purpose of this study was to determine if quantitative measurements of regional asynergy add independent prognostic information to global ejection fraction in patients with chronic coronary artery disease. Four hundred eighty-six patients with a history of Q-wave myocardial infarction who underwent gated-equilibrium radionuclide angiography at least 3 months after infarction were monitored for a median duration of 4.7 years. During follow-up there were 95 deaths. Four of five regional asynergy indexes analyzed were associated with overall mortality. The strength of the association between overall mortality and the index that proved to be optimal (univariate chi2 = 26.4, p < 0.001) was stronger than for global ejection fraction (univariate chi2 = 21.5, p < 0.001). For patients with global ejection fraction <40%, 4-year survival was 87% for those with a low asynergy index versus 65% for those with a high asynergy index (p = 0.016). In conclusion, indexes of regional asynergy add independent prognostic information to global left ventricular ejection fraction.

译文

这项研究的目的是确定是否定量测量区域性无力增加慢性冠状动脉疾病患者总射血分数的独立的预后信息。在梗死后至少3个月接受门控平衡放射性核素血管造影的466例有Q波心肌梗塞病史的患者的中位持续时间为4.7年。在随访期间,有95人死亡。所分析的五个区域无力指数中有四个与总体死亡率相关。总死亡率和被证明是最佳指标(单变量chi2 = 26.4,p <0.001)之间的关联强度要强于总体射血分数(单变量chi2 = 21.5,p <0.001)。对于总体射血分数<40%的患者,低无反应指数的患者的4年生存率为87%,而无高反应指数的患者的4年生存率为65%(p = 0.016)。综上所述,区域无力指标为整体左心室射血分数增加了独立的预后信息。

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