INTRODUCTION:Recent studies suggest that Alzheimer's disease (AD) biomarker disclosure has no discernable psychological impact on cognitively healthy persons. Far less is known about how such results affect symptomatic individuals and their caregivers. METHODS:Randomized controlled trial of 82 mild cognitive impairment (MCI) patient and caregiver dyads (total n = 164) to determine the effect of receiving amyloid positron emission tomography results on understanding of, and perceived efficacy to cope with, MCI over 52 weeks of follow-up. RESULTS:Gains in the primary outcomes were not consistently observed. Amyloid negative patients reported greater perceived ambiguity regarding MCI at follow-up, while moderate and sustained emotional distress was observed in patients, and to a lesser extent, caregivers, of those who were amyloid positive. There was no corresponding increase in depressive symptoms. DISCUSSION:These findings point to the possibility that both MCI patients and caregivers may need emotional support after the disclosure of amyloid scan results.

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简介:最近的研究表明,阿尔茨海默氏病(AD)生物标志物的披露对认知健康的人没有明显的心理影响。对于这样的结果如何影响有症状的个体及其照顾者,人们所知甚少。
方法:随机对照试验对82例轻度认知障碍(MCI)患者和护理人员进行了研究(总计n = 164),以确定接受淀粉样蛋白正电子发射断层扫描结果对52个月的理解和应对MCI的效果跟进。
结果:未始终观察到主要结局的获益。淀粉样蛋白阴性的患者在随访中报告了对MCI更大的模糊性,而在淀粉样蛋白阳性的患者中,以及较少程度上的看护者,观察到了中度和持续的情绪困扰。抑郁症状没有相应增加。
讨论:这些发现表明,MCI患者和看护者在淀粉样蛋白扫描结果公布后可能都需要情感支持。

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