Aging predisposes to hepatic dysfunction and inflammation that can contribute to the development of non-alcoholic fatty liver disease. Spirulina, a cyanobacterium used as a food additive or food supplement, has been shown to impact immune function. We have tested the potential hepatoprotective effect of a Spirulina in aged mice and to determine whether these effects can be related to a modulation of the gut microbiota. Old mice have been fed a standard diet supplemented with or without 5% Spirulina for six weeks. Among several changes of gut microbiota composition, an increase in Roseburia and Lactobacillus proportions occurs upon Spirulina treatment. Interestingly, parameters related to the innate immunity are upregulated in the small intestine of Spirulina-treated mice. Furthermore, the supplementation with Spirulina reduces several hepatic inflammatory and oxidative stress markers that are upregulated in old mice versus young mice. We conclude that the oral administration of a Spirulina is able to modulate the gut microbiota and to activate the immune system in the gut, a mechanism that may be involved in the improvement of the hepatic inflammation in aged mice. Those data open the way to new therapeutic tools in the management of immune alterations in aging, based on gut microbe-host interactions.

译文

:衰老易患肝功能障碍和炎症,可导致非酒精性脂肪肝疾病的发展。螺旋藻是一种用作食品添加剂或食品补充剂的蓝细菌,已显示会影响免疫功能。我们已经测试了螺旋藻对老年小鼠的潜在肝保护作用,并确定这些作用是否与肠道菌群的调节有关。老老鼠已经接受了补充或不加入5%螺旋藻的标准饮食,持续了六周。在肠道菌群组成的几种变化中,螺旋藻治疗后玫瑰果菌和乳杆菌的比例增加。有趣的是,在螺旋藻治疗小鼠的小肠中,与先天免疫有关的参数被上调。此外,螺旋藻的补充减少了在老年小鼠与年轻小鼠中上调的几种肝炎性和氧化应激标志物。我们得出的结论是,螺旋藻的口服给药能够调节肠道菌群并激活肠道免疫系统,该机制可能与改善老年小鼠的肝脏炎症有关。这些数据基于肠道微生物与宿主之间的相互作用,为处理衰老中的免疫变化提供了新的治疗手段。

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