OBJECTIVES:Performance evaluation of a fully automated system for calculating computed tomography (CT) coronary artery calcium scores from contrast medium-enhanced coronary CT angiography (cCTA) studies. METHODS:One hundred and twenty-seven patients (58 ± 11 years, 71 men) who had undergone cCTA as well as an unenhanced CT calcium scoring study where included. Calcium scores were computed from cCTA by an automated image processing algorithm and compared with calcium scores obtained by standard manual assessment of unenhanced CT calcium scoring studies. Results were compared vis-a-vis (1) absolute calcium score values, (2) age-, gender- and race-dependent percentiles, and (3) commonly used calcium score risk classification categories. RESULTS:One hundred and nineteen out of 127 (93.7%) studies were successfully processed. Mean Agatston calcium score values obtained by traditional non-contrast CT calcium scoring studies and derived from contrast medium-enhanced cCTA did not significantly differ (235.6 ± 430.5 vs 262.0 ± 499.5; P > 0.05). Calcium score risk categories and Multi-Ethnic Study of Atherosclerosis (MESA) percentiles showed very high correlation (Spearman rank correlation coefficient = 0.97, P < 0.0001/0.95, P < 0.0001) between the two approaches. CONCLUSIONS:Calcium score values automatically computed from cCTA are highly correlated with standard unenhanced CT calcium scoring studies. These results suggest a radiation dose- and time-saving potential when deriving calcium scores from cCTA studies without a preceding unenhanced CT calcium scoring study.

译文

目的:从造影剂增强型冠状动脉CT血管造影(cCTA)研究中计算计算机断层扫描(CT)冠状动脉钙分数的全自动系统的性能评估。
方法:127例患者(58岁±11岁,男71例)接受了cCTA以及一项未经增强的CT钙评分研究。通过自动图像处理算法从cCTA计算钙分数,并将其与通过标准人工评估未增强的CT钙评分研究获得的钙分数进行比较。相对于(1)绝对钙分数值,(2)年龄,性别和种族依赖性百分位数,以及(3)常用钙分数风险分类类别,比较了结果。
结果:127项研究中有119项(93.7%)得到了成功处理。通过传统的非对比CT钙评分研究获得的,从造影剂增强的cCTA得出的平均Agatston钙评分值没有显着差异(235.6±430.5 vs 262.0±499.5; P> 0.05)。两种方法之间的钙得分风险类别和动脉粥样硬化(MESA)百分位数的多民族研究显示出非常高的相关性(Spearman等级相关系数= 0.97,P <0.0001 / 0.95,P <10.0001)。
结论:从cCTA自动计算的钙评分值与标准的未增强CT钙评分研究高度相关。这些结果表明,从cCTA研究获得钙分数时,无需进行先前的未增强CT钙评分研究,就可以节省辐射剂量和节省时间。

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