Many phytochemicals, the bioactive nonnutrient compounds found in plant foods, possess biologic effects associated with reduced risk of various diseases such as cancer. Genetic variation in pathways affecting absorption, metabolism, and distribution of phytochemicals is likely to influence exposure at the tissue level, thus modifying disease risk in individuals. Few studies have examined these gene-phytochemical interactions in humans. In this review, we discuss the sources of variation in metabolism and disposition of phytochemicals, and focus on two aspects of phytochemical handling that have received some attention: the impact of intestinal bacteria and genetically polymorphic phase II, conjugating enzymes.

译文

:许多植物性化学物质是植物性食品中发现的具有生物活性的非营养性化合物,具有与降低各种疾病(如癌症)风险相关的生物作用。影响植物化学物质吸收,代谢和分布的途径中的遗传变异可能会影响组织水平的暴露,从而改变个体的疾病风险。很少有研究检查人类中的这些基因-植物化学相互作用。在这篇综述中,我们讨论了植物化学物质代谢和处置变化的来源,并着重研究了受到关注的植物化学物质处理的两个方面:肠道细菌和遗传多态性II期的影响,结合酶。

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