OBJECTIVE:To examine the association between body mass index (BMI) and cognitive decline (CD) due to Mild Cognitive Impairment (MCI), Alzheimer's Disease (AD), and Vascular Dementia (VaD). DESIGN AND SETTING:The subjects aged ≥ 65 years were recruited prospectively from the Geriatrics Clinic of Gulhane Medical School, between 2004 and 2008 years. PARTICIPANTS:1302 patients were included in the study. MEASUREMENTS:Cognitive status, clinical diagnosis of CD (MCI, AD, and VaD) and clinical and environmental risk factors were evaluated by comprehensive geriatric assesment. Finally, the subjects were categorized into two groups according to having CD or not. RESULTS:905 (69.5%) subjects were not having CD whereas 397 (30.5%) patients with CD. Of the patients with CD, 140 (10.4%) had MCI, 227 (16.9%) AD, and 30 (2.2%) VaD. After adjustment for confounding with a model for multiple regression analysis, age (OR=1.054; CI:1.027-1.083; p < 0.001) and family history of dementia (OR=1.662; CI:1.038-2.660; p=0.034) were found to be independent risk factors for CD. Also, overweight (OR=0.594; CI:0.370-0.952; p=0.03) and obese (OR=0.396; CI:0.242-0.649; p < 0.001), and high education level (OR=0.640; CI:0.451-0.908; p=0.012) were found to be independent protective factors for CD. CONCLUSIONS:We found the risk of CD decreases in overweight and obese elderly. The results indicate that the primary prevention should not only consider risk factors, but must also take anthropometric data into consideration in order to identify persons at high risk for CD.

译文

目的:探讨由于轻度认知障碍(MCI),阿尔茨海默氏病(AD)和血管性痴呆(VaD)引起的体重指数(BMI)与认知下降(CD)的关联。
设计与地点:年龄≥65岁的受试者是从2004年至2008年间从古尔汉医学院的老年医学诊所前瞻性招募的。
对象:1302例患者被纳入研究。
测量:通过全面的老年医学评估来评估认知状态,CD的临床诊断(MCI,AD和VaD)以及临床和环境危险因素。最后,根据是否有CD将受试者分为两组。
结果:905名(69.5%)患者未患有CD,而397名(30.5%)患者患有CD。在CD患者中,有140名(10.4%)患有MCI,227名(16.9%)AD和30名(2.2%)VaD。用多元回归分析模型进行混淆调整后,发现年龄(OR = 1.054; CI:1.027-1.083; p <0.001)和痴呆症家族史(OR = 1.662; CI:1.038-2.660; p = 0.034)是CD的独立危险因素。此外,超重(OR = 0.594; CI:0.370-0.952; p = 0.03)和肥胖(OR = 0.396; CI:0.242-0.649; p <0.001)和高学历(OR = 0.640; CI:0.451-0.908) ; p = 0.012)是CD的独立保护因子。
结论:我们发现超重和肥胖的老年人CD降低的风险。结果表明,初级预防不仅应考虑危险因素,而且还必须考虑人体测量学数据,以识别高危人群。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录