INTRODUCTION:the potential health impacts due to the decommissioned Nuclear power plants (NPP) located in Borgo Sabotino and Garigliano in Central Italy (active from the early 1960s to the late 1980s) have raised several concerns. Brain, thyroid, breast and lung cancer and leukaemia have been associated with exposure to ionizing radiations, but the health effects of nuclear plants on the resident populations are controversial.
OBJECTIVE:to evaluate whether living close to NPPs is associated with an increased risk of cancer incidence and mortality.
METHODS:we defined a cohort of residents within 7 km from the NPPs during the period 1996-2002. Individual follow-up for vital status at 01.01.2007 was conducted using municipality data. Gender specific Standardized Incidence and Mortality Ratios, adjusted for age, were calculated (SIR and SMR) using the regional population as reference. Each participant's address was assigned to a distance from the NPP on the basis of a GIS. A relative risk (RR, CI95%), adjusted for age and socioeconomic status, was calculated in 3 bands of increasing radius from the plants: 0-2, 2-4, and 4-7 km (reference group), using a Poisson regression model.
RESULTS:the cohort was of 39,775 people, 32%of whom lived near (0-4 km) the NPP. No differences in mortality was found when comparing the cohort with the regional population; among women living within 7 km from the NPP, we found thyroid cancer incidence higher than expected (SIR 1.53 CI95% 1.18-1.95). However, when the analysis was conducted on the basis of the distance from the NPP, we found a statistically significant increase in male mortality only for causes unrelated to radiation exposure (all causes, stomach cancer, and cardiovascular diseases). No mortality excess was observed among women living close to the NPPs. No statistically significant distance-related gradient was observed for cancer incidence both in men and women.
CONCLUSIONS:living close to the NPP was not associated with mortality for causes related to radiation exposure. However, the results suggest to continue the epidemiological surveillance of the population.
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【[Cancer incidence and mortality in the cohort of residents close to the Italian nuclear power plants of Borgo Sabotino and Garigliano].].
【靠近意大利Borgo Sabotino和Garigliano核电厂的居民队列中的癌症发生率和死亡率。】
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简介：位于意大利中部的Borgo Sabotino和Garigliano（从1960年代初到1980年代后期活跃）的退役核电站（NPP）对健康的潜在影响引起了人们的关注。脑，甲状腺，乳腺癌，肺癌和白血病与暴露于电离辐射有关，但核植物对常住人口的健康影响尚存争议。
目的：评估生活在核电厂附近是否与增加的癌症发病率和死亡率风险有关。
方法：我们定义了1996-2002年期间距离核电厂7公里以内的居民群。使用市政数据对2007年1月1日的生命状况进行了个人随访。使用区域人口作为参考，计算了按年龄调整的按性别划分的标准发病率和死亡率（SIR和SMR）。根据GIS，将每个参与者的地址分配给距NPP一段距离。根据年龄和社会经济状况调整了相对风险（RR，CI95％），使用泊松在来自植物的半径逐渐增加的3个波段中计算得出：0-2、2-4和4-7 km（参考组）回归模型。
结果：该队列有39,775人，其中32％生活在NPP附近（0-4 km）。将队列与区域人口进行比较时，没有发现死亡率差异。在距NPP 7公里以内的女性中，我们发现甲状腺癌的发病率高于预期（SIR 1.53 CI95％1.18-1.95）。但是，当根据与NPP的距离进行分析时，我们发现统计学上仅在与辐射暴露无关的原因（所有原因，胃癌和心血管疾病）上男性死亡率有显着增加。在生活在国家淘汰计划附近的妇女中，没有发现死亡率过高的现象。在男性和女性中，均未观察到癌症发病率具有统计学意义的距离相关梯度。
结论：接近NPP与因辐射暴露引起的死亡率无关。但是，结果表明要继续对该人群进行流行病学监测。
目的：评估生活在核电厂附近是否与增加的癌症发病率和死亡率风险有关。
方法：我们定义了1996-2002年期间距离核电厂7公里以内的居民群。使用市政数据对2007年1月1日的生命状况进行了个人随访。使用区域人口作为参考，计算了按年龄调整的按性别划分的标准发病率和死亡率（SIR和SMR）。根据GIS，将每个参与者的地址分配给距NPP一段距离。根据年龄和社会经济状况调整了相对风险（RR，CI95％），使用泊松在来自植物的半径逐渐增加的3个波段中计算得出：0-2、2-4和4-7 km（参考组）回归模型。
结果：该队列有39,775人，其中32％生活在NPP附近（0-4 km）。将队列与区域人口进行比较时，没有发现死亡率差异。在距NPP 7公里以内的女性中，我们发现甲状腺癌的发病率高于预期（SIR 1.53 CI95％1.18-1.95）。但是，当根据与NPP的距离进行分析时，我们发现统计学上仅在与辐射暴露无关的原因（所有原因，胃癌和心血管疾病）上男性死亡率有显着增加。在生活在国家淘汰计划附近的妇女中，没有发现死亡率过高的现象。在男性和女性中，均未观察到癌症发病率具有统计学意义的距离相关梯度。
结论：接近NPP与因辐射暴露引起的死亡率无关。但是，结果表明要继续对该人群进行流行病学监测。
