This study used resting-state functional magnetic resonance imaging (fMRI) to investigate whether functional connectivity is altered in people developing post-traumatic stress disorder (PTSD) following recent trauma. Sixty-two participants who had experienced recent acute traumatic events underwent a 7.3 min resting fMRI scan within 2 days post accident. Of these, 22 participants were diagnosed with PTSD within 1 to 6 months. Nineteen age- and sex-matched subjects without PTSD were selected as the trauma-exposed control group. Posterior cingulate cortex connectivity was determined from 17 PTSD patients and 15 control subjects by investigating synchronic low-frequency fMRI signal fluctuations using a temporal correlation method. To assess the relationship between PTSD symptom severity and PCC connectivity, the contrast image representing areas correlated with the PCC was correlated with the 17 PTSD subjects' Clinician Administered PTSD Scale (CAPS) scores at diagnosis. Compared with the control group, PTSD patients exhibited decreased functional connectivity in the right lingual and right middle temporal gyri, and left lingual/posterior cingulate cortex. The left inferior temporal gyrus, right middle temporal gyrus, left middle temporal gyrus/insula, left medial frontal lobe/anterior cingulate cortex, and right medial frontal gyrus also showed increased connectivity within two days post accident. A negative correlation was found between PCC connectivity and CAPS scores in the left medial prefrontal cortex (mPFC). These results suggest that patients who develop PTSD exhibit different resting-state patterns of neuronal activity following recent trauma. Abnormal FC of mPFC may be a major risk factor predisposing patients to the development of PTSD.

译文

:这项研究使用静止状态功能磁共振成像(fMRI)来研究在最近的创伤后发展为创伤后应激障碍(PTSD)的人们的功能连接性是否发生了改变。事故发生后两天内,最近经历过急性创伤事件的62名参与者进行了7.3分钟的静息功能磁共振成像扫描。其中,有22名参与者在1-6个月内被诊断为PTSD。选择十九名没有PTSD的年龄和性别匹配的受试者作为暴露于创伤的对照组。通过使用时间相关性方法调查同步低频fMRI信号波动,从17例PTSD患者和15例对照受试者中确定了扣带后部皮层的连通性。为了评估PTSD症状严重程度与PCC连通性之间的关系,将代表与PCC相关的区域的对比图像与17 PTSD受试者在诊断时由临床医生管理的PTSD量表(CAPS)评分相关联。与对照组相比,PTSD患者在右舌和右颞中回以及左舌/后扣带皮层的功能连接性降低。左下颞回,右中颞回,左中颞回/孤立,左内侧额叶/前扣带回皮层以及右内侧额回在事故发生后两天内也显示出增强的连通性。左内侧前额叶皮层(mPFC)中的PCC连接性和CAPS得分之间呈负相关。这些结果表明,在最近的创伤之后,发展为PTSD的患者表现出不同的静止状态神经元活动。 mPFC的FC异常可能是使患者易患PTSD的主要危险因素。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录