We investigated immunoglobulin G (IgG) subclass antibody responses to Plasmodium falciparum merozoite surface protein 1 (MSP-1) and MSP-2 in 112 malaria-exposed subjects in Brazil. IgG3 polarization was primarily epitope driven, being little affected by cumulative or current exposure to malaria and not affected by a subject's age and Fcgamma receptor IIA genotype.
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【Factors associated with immunoglobulin G subclass polarization in naturally acquired antibodies to Plasmodium falciparum merozoite surface proteins: a cross-sectional survey in Brazilian Amazonia.].
【自然获得的抗恶性疟原虫裂殖子表面蛋白的抗体中与免疫球蛋白G亚类极化相关的因素：巴西亚马逊地区的横断面调查。】
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DOI：10.1128/CVI.00095-06文章类型：杂志文章
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：我们调查了巴西112名疟疾暴露者对恶性疟原虫裂殖子表面蛋白1（MSP-1）和MSP-2的免疫球蛋白G（IgG）亚类抗体反应。 IgG3极化主要是由表位驱动的，几乎不受累积或当前暴露于疟疾的影响，并且不受受试者的年龄和Fcgamma受体IIA基因型的影响。
