PROBLEM:To determine whether an increase in the number of previous miscarriages in recurrent spontaneous abortion patients is a risk factor in subsequent pregnancies with paternal lymphocyte immunotherapy. METHOD OF STUDY:Live birth rates with reference to previous abortion numbers in recurrent spontaneous abortion patients were statistically compared between paternal lymphocyte immunotherapy and control groups, the latter retrospectively researched using historical data before 1981 in our clinic. RESULTS:The overall live birth rate was 73% (169/232) in the immunotherapy group, and 48% (47/97) in controls (P <0.05). According to previous abortion numbers, the rates were 77% (114/148) versus 55% (36/65) (P < 0.05) for three previous abortions, 70% (40/57) versus 38% (8/21) (P < 0.05) for four and 56% (15/27) versus 27% (3/11) (not significant) for five, in the study and control groups, respectively. CONCLUSIONS:The results confirm the efficacy of paternal lymphocyte immunotherapy, but demonstrate that the success rate deteriorates with the number of previous miscarriages.

译文

问题:要确定复发性自然流产患者先前流产次数的增加是否是随后通过父系淋巴细胞免疫疗法怀孕的危险因素。
研究方法:对父本淋巴细胞免疫疗法与对照组之间在复发性自然流产患者中参考先前流产数的活产率进行统计学比较,对后者进行回顾性研究,其依据是我们1981年以前的临床资料。
结果:免疫治疗组的总活产率为73%(169/232),对照组为48%(47/97)(P <0.05)。根据先前的堕胎次数,前三次堕胎的比率分别为77%(114/148)和55%(36/65)(P <0.05),分别为70%(40/57)和38%(8/21)(在研究组和对照组中,分别为4%和56%(15/27)的P <0.05),而5人分别为27%(3/11)(不显着)。
结论:该结果证实了父本淋巴细胞免疫疗法的有效性,但证明成功率随先前流产次数的增加而降低。

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