We conducted a prospective study of 60 patients in a tertiary care referral center to ascertain the status of cell-mediated immunity as determined by delayed hypersensitivity reactions in patients with nasopharyngeal carcinoma (NPC) or allergic rhinitis. Delayed hypersensitivity as detected by Mantoux testing is generally accepted as a reflection of the level of cell-mediated immunoactivity-the less hypersensitivity reaction that occurs, the lower the level of immunoactivity is, and vice versa. Our study population was made up of three groups: 20 newly diagnosed patients with NPC (pretreatment), 20 age- and sex-matched patients with allergic rhinitis, and 20 matched controls without either disease. A negative Mantoux test (0- to 5-mm induration) was seen in 13 patients with NPC (65.0%), in 17 patients with allergic rhinitis (85.0%), and in 16 controls (80.0%); none of these differences was statistically significant. However, it is interesting that while the NPC group had the lowest percentage of negative Mantoux results overall, it had the highest percentage of patients who had no reaction at all (i.e., 0-mm induration); a complete absence of any reaction was seen in 7 of the 13 Mantoux-negative NPC patients (53.8%), compared with 2 of the 17 Mantoux-negative allergic rhinitis patients (11.8%) and 3 of the 16 Mantoux-negative controls (18.8%). An absence of a reaction generally indicates a very limited degree of cell-mediated immunoactivity. Therefore, we conclude that patients with NPC appear to have significantly less cell-mediated immunity than do patients with allergic rhinitis and normal controls; no statistically significant difference was noted between the latter two groups.

译文

:我们在三级医疗转诊中心对60例患者进行了一项前瞻性研究,以确定由鼻咽癌(NPC)或变应性鼻炎患者的迟发性超敏反应确定的细胞介导的免疫状态。通过Mantoux测试检测到的迟发型超敏反应通常被认为是细胞介导的免疫活性水平的反映-发生的超敏反应越少,免疫活性水平就越低,反之亦然。我们的研究人群由三组组成:20名新诊断的NPC(预处理)患者,20名年龄和性别匹配的变应性鼻炎患者以及20个无任何疾病的匹配对照组。在13例NPC患者(65.0%),17例过敏性鼻炎患者(85.0%)和16例对照(80.0%)中,Mantoux试验阴性(硬结度为0至5mm)。这些差异均无统计学意义。然而,有趣的是,尽管NPC组的总体Mantoux阴性结果百分比最低,但完全没有反应(即硬结0毫米)的患者比例最高。 13名Mantoux阴性NPC患者中有7名完全没有反应(53.8%),而17名Mantoux阴性变应性鼻炎患者中有2名(11.8%)和16名Mantoux阴性对照中有3名(18.8) %)。不存在反应通常表明细胞介导的免疫活性非常有限。因此,我们得出结论,与变应性鼻炎和正常对照组相比,NPC患者似乎具有明显更少的细胞介导的免疫力。后两组之间没有统计学上的显着差异。

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