The aim of this work is to determine the effect of chronic immobilization stress on kinetics and dosimetry of 67Ga in a mouse model. A control group (CG) and a stress group (SG), each with 15 mice, were included in the study, and the latter group was subjected to a chronic immobilization stress model 2 h daily for 14 consecutive days. At day 13, 67Ga-citrate was administered intraperitoneally (11.24 ± 0.44 MBq) to each mouse. Then, sets of three mice were obtained sequentially at 24, 36, 48, 60 and 72 h, in which the radionuclide activity was measured with an activity counter. The 67Ga biokinetic data showed a fast blood clearance in the SG, with a mean residence time of 0.06 h. The calculated mean radiation absorbed doses were: liver (2.45 × 10-03 Gy), heart (3.17 × 10-04 Gy) and kidney (1.88 × 10-04 Gy) in the SG. The results show that stress reduced weight gain by approximately 13% and also increased adrenal gland weight by 26%. On the other hand, chronic stress accelerates 67Ga clearance after 24 h compared to normal conditions. It is concluded that murine organisms under chronic immobilization stress have higher gallium-67 clearance rates, decreasing the cumulated activity and absorbed dose in all organs.

译文

:这项工作的目的是确定长期固定应力对小鼠模型中67Ga动力学和剂量学的影响。对照组(CG)和压力组(SG)各自有15只小鼠,并且该组每天2h接受慢性固定应激模型,连续14天。在第13天,向每只小鼠腹膜内给予67Ga柠檬酸(11.24±0.44MBq)。然后,在24、36、48、60和72h依次获得三只小鼠的集合,其中用活性计数器测量放射性核素的活性。 67Ga的生物动力学数据显示SG中血液快速清除,平均停留时间为0.06 h。计算得出的平均辐射吸收剂量为:SG中的肝脏(2.45××10-03 Gy),心脏(3.17××10-04 Gy)和肾脏(1.88××10-04 Gy)。结果表明,压力使体重增加减少了约13%,肾上腺重量也增加了26%。另一方面,与正常情况相比,慢性应激会在24小时后加速67Ga的清除。结论是,在慢性固定压力下的鼠类生物具有较高的镓67清除率,从而降低了所有器官的累积活性和吸收剂量。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录