Screening programs can reduce the burden of disease, however, they can be associated with raised levels of anxiety. The risk of endometrial and ovarian cancer is increased in hereditary nonpolyposis colorectal cancer (HNPCC). There is no prospective evidence to support screening for gynecological disease in HNPCC, however, current recommendations include the use of ultrasound and endometrial biopsy. This study assesses the impact of screening for gynecological cancer on self-reported symptoms of anxiety, depression, and perceptions of health. Women from HNPCC families attending gynecological screening (n = 26) completed the Hospital Anxiety and Depression Scale and the ShortForm36v2 questionnaires prior to screening with transvaginal ultrasound, outpatient/office hysteroscopy, endometrial biopsy, and ovarian tumor marker assessment (CA125). The same questionnaires were completed at 3 and 6 months following screening (15/26). Women in HNPCC families attending for gynecological screening did not have excess symptoms of anxiety or depression at baseline in subjective comparison to other populations. The process of screening and false positive screening results had no significant impact on symptoms of anxiety and depression or perceptions of health. We conclude that within the limitations of analysis in this small study group, screening for gynecological disease in HNPCC does not appear to be associated with any psychological morbidity.

译文

:筛查程序可以减轻疾病的负担,但是,它们可能与焦虑水平上升有关。遗传性非息肉病性结直肠癌(HNPCC)会增加子宫内膜和卵巢癌的风险。没有前瞻性证据支持筛查HNPCC中的妇科疾病,但是,当前的建议包括使用超声和子宫内膜活检。这项研究评估了筛查妇科癌症对自我报告的焦虑,抑郁和健康观症状的影响。接受妇科筛查的HNPCC家庭妇女(n = 26)在通过阴道超声,门诊/宫腔镜检查,子宫内膜活检和卵巢肿瘤标志物评估(CA125)进行筛查之前,完成了医院焦虑和抑郁量表和ShortForm36v2问卷。筛选后的3个月和6个月完成了相同的问卷调查(15/26)。与其他人群相比,从主观上看,参加妇科筛查的HNPCC家庭中的妇女在基线时没有过多的焦虑或抑郁症状。筛查的过程和假阳性筛查结果对焦虑和抑郁症状或健康感知没有显着影响。我们得出的结论是,在这个小型研究小组的分析范围内,HNPCC妇科疾病筛查似乎与任何心理疾病均不相关。

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