The exact mechanism for the decrease in intestinal calcium absorption with age is not yet understood. A decrease with age in serum 1,25-dihydroxyvitamin D (1,25(OH)2D) or a decrease in the intestinal vitamin D receptor (VDR) protein concentration are possible causes. The objective of this study was to examine the effect of age on these factors. Fifty-nine young women age 25-35 years were compared with 41 elderly women age 65-83 years who underwent measurements of VDR, calcium absorption using a 20 mg and 100 mg calcium carrier, and calciotropic hormones. Calcium absorption by both tests was lower in the elderly women compared with the young women (p < 0.05). Serum 1,25(OH)2D and duodenal VDR protein concentration were not significantly different between the two age groups. Serum 1,25(OH)2D correlated with the 20 mg calcium absorption test in both young (r = 0.35, p < 0.007) and elderly women (r = 0.58, p < 0.0001) and with the 100 mg calcium absorption in the elderly (r = 0.32; p < 0.05). VDR did not correlate with calcium absorption in young women or elderly women, nor did VDR correlate with serum 1,25(OH)2D and serum 25-hydroxyvitamin D. In summary, the decrease in calcium absorption cannot be explained by a decrease in intestinal VDR. The correlation between serum 1,25(OH)2D and both calcium absorption tests only accounts for 12-30% of the variance in the age-related change in the calcium absorption tests. Other factors, not yet understood, are responsible for the decline in calcium absorption with age.

译文

随着年龄的增长,肠道钙吸收减少的确切机制尚不清楚。血清1,25-二羟基维生素D(1,25(OH)2D)随年龄的减少或肠道维生素D受体(VDR)蛋白质浓度的减少是可能的原因。这项研究的目的是研究年龄对这些因素的影响。比较了59名年龄在25-35岁之间的年轻女性与41位年龄在65-83岁之间的女性,这些女性进行了VDR测量,使用20 mg和100 mg钙载体的钙吸收量以及亲钙性激素。与年轻女性相比,老年女性的两种测试中的钙吸收均较低(p <0.05)。在两个年龄组之间,血清1,25(OH)2D和十二指肠VDR蛋白浓度无显着差异。血清1,25(OH)2D与年轻(r = 0.35,p <0.007)和老年妇女(r = 0.58,p <0.0001)的20 mg钙吸收测试以及老年人的100 mg钙吸收相关(r = 0.32; p <0.05)。 VDR与年轻妇女或老年妇女的钙吸收无关,也不与血清1,25(OH)2D和血清25-羟维生素D相关。 VDR。血清1,25(OH)2D与两种钙吸收试验之间的相关性仅占钙吸收试验中与年龄相关的变化方差的12%至30%。钙吸收随着年龄的增长而下降的其他原因尚不明确。

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