BACKGROUND:Interleukin-17 (IL-17), which is secreted by Th17 cells, is a proinflammatory cytokine that is implicated in the pathogenesis of multiple sclerosis (MS) and plays a role in nonresponse of MS patients to interferon-β (IFN-β) therapy. OBJECTIVES:The purpose of this study was to establish a correlation between nonresponders (NR) and IL-17A serum titers and binding antibodies (BAbs) to IFN-β, as well as to find a correlation between IL-17A serum levels and other features of MS patients. METHODS:Our prospective study included 72 inactive relapsing-remitting multiple sclerosis (RRMS) patients that had been treated for at least 18 months with IFN-β and 15 healthy subjects. We determined the serum levels of IL-17A and of BAbs. IL-17A levels were considered elevated (IL-17A+) if the recorded value was greater than 1.6 pg/ml. RESULTS:Twenty-seven patients (37.5%) were NR and had a significantly higher serum IL-17A level compared to the responders group. Nineteen patients (26.4%) were IL-17A+ and had had a significantly higher number of relapses in the previous year and a higher Expanded Disability Status Score. The majority of IL-17A+ patients were NR and had a shorter MS duration. CONCLUSIONS:RRMS patients with high serum IL-17A levels do not respond well to IFN-β therapy and have shorter MS duration compared to patients with low IL-17A levels. This response is not influenced by the presence of BAbs.

译文

背景:Th17细胞分泌的白细胞介素17(IL-17)是一种促炎细胞因子,与多发性硬化症(MS)的发病机制有关,并且在MS患者对干扰素-β(IFN- β)疗法。
目的:本研究的目的是建立无应答者(NR)与IL-17A血清滴度和针对IFN-β的结合抗体(BAbs)之间的相关性,以及找出IL-17A血清水平与其他特征之间的相关性MS患者。
方法:我们的前瞻性研究包括72例接受IFN-β治疗至少18个月的非活动性复发缓解型多发性硬化症(RRMS)患者和15名健康受试者。我们确定了IL-17A和BAbs的血清水平。如果记录值大于1.6 pg / ml,则认为IL-17A水平升高(IL-17A)。
结果:27名患者(37.5%)为NR,与应答者组相比,血清IL-17A水平显着更高。 19名患者(26.4%)为IL-17A,在前一年中复发率明显更高,而“扩展残疾状态评分”更高。大多数IL-17A患者为NR,MS病程较短。
结论:与低IL-17A水平的患者相比,血清IL-17A水平高的RRMS患者对IFN-β治疗的反应不佳,MS病程较短。该反应不受BAbs的存在的影响。

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