UNLABELLED:Radiolabeled benzamides have recently been introduced for the detection of melanoma. We evaluated the potential clinical applicability of 123I-N-(2-diethylaminoethyl) 4-iodobenzamide ([123I]IDAB) for SPECT imaging of ocular melanoma.

METHODS:Fourteen patients were studied, 10 with or suspected of malignant ocular melanoma and four with ocular naevi. All patients underwent SPECT imaging of the head and whole-body scintigraphy 4-5 hr after injection of 170 MBq [123I]IDAB.

RESULTS:A definite tracer hyperfixation was observed in the pathological eye in 9 of 10 (90%) patients with ocular melanoma. The pathological-to-normal eye ratio averaged 1.46 (range 1.07-2.86). The melanoma nature of the scintigraphic lesions was confirmed after enucleation in eight cases and by clinical evolution in two. A false-negative scan was reported in a patient with a small and hypochromic lesion. In patients with ocular naevi, no false-positive scintigrams were documented.

CONCLUSION:Iodine-123-IDAB scintigraphy may contribute significantly to decide about enucleation in cases where some doubt persists with conventional techniques.

译文

UNLABELLED :最近已引入放射性标记的苯甲酰胺来检测黑色素瘤。我们评估了123I-N-(2-二乙基氨基乙基)4-碘苯甲酰胺([123I] IDAB)在眼黑色素瘤SPECT成像中的潜在临床应用性。

方法:14例患者研究发现,有10例疑似恶性眼黑色素瘤或疑似恶性眼黑色素瘤,有4例恶性眼黑色素瘤。所有患者在注射170 MBq [123I] IDAB后4-5小时都进行了头部和全身闪烁显像的SPECT成像。 10例(90%)眼黑色素瘤患者中有9例病理性眼病。病理眼与正常眼的比率平均为1.46(范围为1.07-2.86)。摘除后有8例经临床摘除证实了闪烁体病变的黑色素瘤性质,有2例经临床演变得到了证实。据报道,病灶较小且呈低色病的患者出现假阴性扫描。

结论:如果对传统方法仍存在疑问,则碘-123-IDAB闪烁显像可能在决定摘除方面有重要作用。

结论:技术。

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